Radiologic-Pathologic Correlation of COVID-19-Associated Acute Disseminated Encephalomyelitis

A 42-year-old woman presented with drooling, slurred speech, inability to walk and talk, a recent positive COVID-19 test. She had two prior hospital admissions within the past week for similar symptoms inconclusive evaluation. MRI of brain demonstrated multifocal white matter hyperintense lesions on fluid-attenuated inversion recovery (FLAIR)/diffusion variable enhancement. These imaging findings have been described in literature are associated inflammatory demyelinating disease, such as acute disseminated encephalomyelitis. The patient subsequently underwent biopsy final diagnosis lesion. To our knowledge, this is first radiologic-pathologic correlation COVID-19-associated